Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid-acting antidepressant effects and summarize how diverse phenomena associated with ketamine’s antidepressant actions – such as cortical excitation, synaptogenesis, and involved molecular determinants – are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain.Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid -acting antidepressant effects and summarize how diverse phenomena associated with ketamine's antidepressant actions - such as cortical excitation, synaptogenesis, and involved molecular determinants - are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).Peer reviewe

CAD systems as a method of research of mechanical properties metal roof support

В работе представлена методика анализа металлических арочных крепей, позволяющая исследовать компьютерную трехмерную модель крепи при различных видах и величинах нагрузок.The paper presents a methodology for the analysis of metal roof support that allows with use of computer explore the three-dimensional model to be fixed for different types and magnitudes of loads

РАСЧЕТ МАГНИТНОГО ПОЛЯ ТРЕХФАЗНЫХ КАБЕЛЬНЫХ ЛИНИЙ ПРИ ДВУСТОРОННЕМ ЗАМЫКАНИИ СОБСТВЕННЫХ ЭКРАНОВ КАБЕЛЕЙ, ОХВАЧЕННЫХ ФЕРРОМАГНИТНЫМИ СЕРДЕЧНИКАМИ

In this paper we obtain compact expressions for the magnetic field shielding factor of a high-voltage three-phase cable line consisting of single-core cables with two-point bonded cable shields and ferromagnetic cores installed. To obtain these expressions we develop the analytical model of the cable line. Following assumptions are made to develop the model: the current distribution in each cable shield is uniform, cylindrical ferromagnetic cores covering the cables are not magnetized to saturation and their magnetic permeability is constant, each of the ferromagnetic cores is magnetized only by the core current and the shield current of the cable that it covers, the magnetic field inside ferromagnetic cores is axisymmetric, the magnetic field is plane-parallel over the entire cable line. We consider common cases of flat and trefoil cable lines. The proposed expressions for the magnetic field shielding factor are verified experimentally. The physical model is made of three cables of the type NA2XSF(L)2Y-110 1´240/70. It is shown that the difference between numerical simulation results and experimental data lays within 15 %.Получены компактные соотношения для расчета эффективности экранирования магнитного поля высоковольтной трехфазной кабельной линии, состоящей из одножильных кабелей, которые охвачены ферромагнитными сердечниками, при двустороннем замыкании собственных экранов. Рассмотрены кабельные линии с укладкой кабелей треугольником и в плоскости. Предложенные соотношения для расчета эффективности экранирования магнитного поля верифицированы экспериментально

Electromagnetic wave refraction at an interface of a double wire medium

Plane-wave reflection and refraction at an interface with a double wire medium is considered. The problem of additional boundary conditions (ABC) in application to wire media is discussed and an ABC-free approach, known in the solid state physics, is used. Expressions for the fields and Poynting vectors of the refracted waves are derived. Directions and values of the power density flow of the refracted waves are found and the conservation of the power flow through the interface is checked. The difference between the results, given by the conventional model of wire media and the model, properly taking into account spatial dispersion, is discussed.Comment: 17 pages, 11 figure

The Plateau de Bure Neutron Monitor: design, operation and Monte-Carlo simulation

This paper describes the Plateau de Bure Neutron Monitor (PdBNM), an instrument providing continuous ground-level measurements of atmospheric secondary neutron flux resulting from the interaction of primary cosmic rays with the Earth's atmosphere. The detector is installed on the Plateau de Bure (Devoluy mountains, south of France, latitude North 44{\deg} 38' 02", longitude East 5{\deg} 54' 26", altitude 2555 m) as a part of the ASTEP Platform (Altitude Single-event effects Test European Platform), a permanent installation dedicated to the study of the impact of terrestrial natural radiation on microelectronics circuit reliability. The present paper reports the neutron monitor design, its operation since August 2008 and its complete numerical simulation using the Monte Carlo codes GEANT4 and MCNPX. We particularly detail the computation of the neutron monitor detection response function for neutrons, muons, protons and pions, the comparison between GEANT4 and MCNPX numerical results and the evaluation of the PdBNM counting rate a function of both the nature and flux of the incident atmospheric particles.Comment: 37 pages, 14 figures, 5 tables; numerical error in GEANT4 particle sourse corrected, section 4.4 was significantly revised. Submitted to IEEE Transactions on Nuclear Scienc

Choosing of optimal start approximation for laplace equation numerically solving

In the last few years, repeatedly increased the role of simulation systems for solution of physical problems, particularly in the microwave and electronics. This article focuses on the promising methods for setting an initial approximation for the numerical solution of the Laplace equation. We investigate Dirichlet problem for a case of two-dimensional area with lime border, numerical scheme for solving this equation is widely knowns it finite difference method. One of the major stages in the algorithm for that numerical solution is choosing of start approximation, usually as the initial values of the unknown function are assumed to be zero, which may serve as a lead to a large number of iterations in finding the numerical solution. It is shown that there is a way to set a start approximation, which can significantly reduce the number of iterations in the solution of the Laplace equation.Keywords: Laplace equation; approximation; net; Dirichlet problem; finite differencemethod

College of Arts and Sciences at Governors State University Announces Winter 2008 Dean’s List

The College of Arts and Sciences at Governors State University recently recognized undergraduate students who earned a 3.7 grade point average or higher during the Winter 2008 trimester

Use of program products for engineering graphics

В работе проведен анализ современных методов повышения эффективности преподавания инженерной графики, используя на занятиях современные технические средства обучения и компьютерные технологии.The analysis of modern methods to improve the effectiveness of engineering graphics teaching using modern teaching aids and computer technology

Innovative forms and methods in the educational process

В работе рассмотрено влияние использования в образовательной деятельности современных инновационных форм и методов представления материала.This article examines the effect of using in the educational activities of contemporary innovative forms and methods presentation of the material

Use of program products for engineering graphics

В работе проведен анализ современных методов повышения эффективности преподавания инженерной графики, используя на занятиях современные технические средства обучения и компьютерные технологии.The analysis of modern methods to improve the effectiveness of engineering graphics teaching using modern teaching aids and computer technology